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The Association between the Myelodysplastic Syndromes and Crohn Disease

Charis Eng, MD, PhD; Francis A. Farraye, MD; Lawrence N. Shulman, MD; Mark A. Peppercorn, MD; Celeste M. Krauss, MD; Jean M. Connors, MD; and Richard M. Stone, MD
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Requests for Reprints: Richard M. Stone, MD, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115.

Current Author Addresses: Drs. Eng and Stone: Division of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115.

Dr. Farraye: Division of Gastroenterology, Harvard Community Health Plan, 2 Fenway Plaza, Boston, MA 02215.

Drs. Shulman and Connors: Division of Hematology and Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.

Dr. Peppercorn: Division of Gastroenterology and Department of Medicine, Center for Inflammatory Bowel Diseases, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215.

Dr. Krauss: Division of Medical Genetics, Harvard Community Health Plan, 185 Dartmouth Street, Boston, MA 02116.

Ann Intern Med. 1992;117(8):661-662. doi:10.7326/0003-4819-117-8-661
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This excerpt has been provided in the absence of an abstract.

The myelodysplastic syndromes are a heterogeneous group of bone marrow stem-cell disorders characterized by peripheral cytopenias and hypercellular dysplastic bone marrows (1, 2). The myelodysplastic syndromes, as defined in the French-American-British classification (2), include refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia. Crohn disease, an inflammatory bowel disease, is characterized by specific pathologic and endoscopic gastrointestinal mucosal findings; these include chronic inflammation, noncaseating granulomas, skip lesions, and aphthous ulcerations (3). Unlike the frequent occurrence of clonal chromosomal abnormalities in the bone marrow cells of patients


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