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New Dosing Regimens for Aminoglycoside Antibiotics

Matthew E. Levison, MD
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Requests for Reprints: Matthew E. Levison, MD, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, PA 19129.

Medical College of Pennsylvania
Philadelphia, PA 19129

Ann Intern Med. 1992;117(8):693-694. doi:10.7326/0003-4819-117-8-693
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This excerpt has been provided in the absence of an abstract.

Aminoglycosides are commonly used because of their broad-spectrum and reliable antimicrobial activity against aerobic gram-negative bacilli, with fewer than 5% of strains resistant. To explain the rationale underlying the novel proposal of single daily dosing of aminoglycosides, I will describe their pharmacodynamics—the relation of the time course of their antimicrobial effect to concentrations of the antibiotic at the site of the infection (1-6).

Administering the total daily dose of aminoglycoside once daily, rather than in divided doses, has recently been proposed to improve efficacy and possibly to reduce toxicity (7). Aminoglycosides have concentration-dependent bactericidal action; that is, larger doses can


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