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Androgens, Lipids, and Cardiovascular Risk

Stephen R. Plymate, MD; and Ronald S. Swerdloff, MD
Ann Intern Med. 1992;117(10):871-872. doi:10.7326/0003-4819-117-10-871
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The incidence of coronary artery disease is significantly higher in men than in women until menopause, after which the incidence of coronary disease is similar in both sexes. Most commonly, these gender differences have been explained by the hormonal milieu and, most specifically, by the actions of sex steroids on the lipid profile. Certainly, the serum high-density lipoprotein (HDL) cholesterol level is lower and triglyceride levels are higher in eugonadal men than in premenopausal women (1). No sex-related differences in serum HDL cholesterol or triglyceride levels have been observed in prepubertal children (2). During male adolescence, plasma HDL cholesterol levels


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