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The Low Efficiency of Maternal-Neonatal Transmission of Hepatitis C Virus: How Certain Are We?

Raymond S. Koff, MD
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Requests for Reprints: Raymond S. Koff, MD, Department of Medicine, Framingham Union Hospital, 115 Lincoln St., Framingham, MA 01701.

University of Massachusetts Medical Center
MetroWest Medical Center
Framingham, MA 01701

Ann Intern Med. 1992;117(11):967-969. doi:10.7326/0003-4819-117-11-967
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Hepatitis C virus (HCV) is a hot topic. Because the literature is constantly expanding, keeping current with new research is no simple task for either the clinician or investigator. The "big bang" of HCV research is readily traced to the brilliant efforts and perseverance of Houghton and colleagues who, working collaboratively with Bradley, cloned the HCV genome (1). This remarkable achievement permitted a proliferation of specific assays to study HCV infection. The humoral immune response to HCV was assessed initially by radioimmunoassay, but the development of first-generation enzyme-linked immunosorbent assays (ELISAs) and recombinant immunoblot assays (RIBAs) and then second-generation assays


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