0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Dietary Risk Factors for the Incidence and Recurrence of Colorectal Adenomatous Polyps: A Case-Control Study

Alfred I. Neugut, MD, PhD; Gail C. Garbowski, MPH; Won Chul Lee, MD; Todd Murray, BA; Jeri W. Nieves, MS; Kenneth A. Forde, MD; Michael R. Treat, MD; Jerome D. Waye, MD; and Cecilia Fenoglio-Preiser, MD
[+] Article and Author Information

From the College of Physicians and Surgeons, Columbia University, and the Mount Sinai School of Medicine, New York, New York; University of Cincinnati Medical Center, Cincinnati, Ohio. Requests for Reprints: Alfred I. Neugut, MD, PhD, Division of Oncology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032. Grant Support: In part by grants from the National Cancer Institute (RO1-CA37196) and the Aaron Diamond Foundation. Dr. Neugut was the recipient of a Preventive Oncology Academic Award (KO7-CA01211) from the National Institutes of Health and was a Fellow of the Andrew Mellon Foundation Program in Epidemiology and Medicine at Columbia University.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1993;118(2):91-95. doi:10.7326/0003-4819-118-2-199301150-00002
Text Size: A A A

Objective: To investigate the association of dietary factors with the incidence and recurrence of colorectal adenomatous polyps.

Design: Two case–control studies.

Setting: Three university-based colonoscopy practices in New York City.

Patients: For the incidence study, 286 patients with pathologically confirmed incident adenomatous polyps (162 men and 124 women) were compared with 480 controls (210 men and 270 women) with no current or previous neoplasia. For the recurrence study, 186 patients with recurrent polyps (130 men and 56 women) were compared with 330 controls (187 men and 143 women). These patients had a history of polyps but no current neoplasia.

Measurements: Structured interviews using the Block food frequency questionnaire were conducted on all participants and were compared over quartiles of crude nutrient intake of total and saturated fat; fiber; protein; carbohydrates; carotene; vitamins A, C, and E; and various food groups. Data were adjusted for age, Quetelet index, and caloric intake by multiple logistic regression for men and women separately.

Results: For incident polyps, elevated adjusted odds ratios (high to low quartile) for women were found for saturated fat (odds ratio, 2.3; 95% CI, 0.9 to 5.8) and the ratio of red meat to chicken and fish intake (odds ratio, 1.9; CI, 1.0 to 3.6). Protective associations were observed for fish and chicken (odds ratio, 0.6; CI, 0.3 to 1.2) and vitamin A intake (odds ratio, 0.4; CI, 0.2 to 0.9). Among women, recurrent polyps showed an association with total dietary fat (odds ratio, 4.4; CI, 1.0 to 19.5), saturated fat (odds ratio, 3.8; CI, 1.0 to 14.9; P = 0.15 for the trend), and total fiber (odds ratio, 0.2; CI, 0.1 to 0.5; P = 0.01) and a borderline association with carbohydrates (odds ratio, 0.3; CI, 0.1 to 1.3; P = 0.10). No consistent relations were observed for men, although increased caloric intake increased the risk for incidence and recurrence in both men and women.

Conclusions: These findings are consistent with previously described relations between diet and the incidence of colon cancer and suggest that, at least in women, dietary modification may be warranted in patients diagnosed with polyps.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)