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Outcome of Patients Hospitalized for Complications after Outpatient Liver Biopsy

Christine H. Janes, MD; and Keith D. Lindor, MD
[+] Article and Author Information

From the Mayo Foundation, Rochester, Minnesota. Requests for Reprints: Keith D. Lindor, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1993;118(2):96-98. doi:10.7326/0003-4819-118-2-199301150-00003
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Objective: To determine the safety of outpatient liver biopsies by analyzing the outcome of patients hospitalized for complications.

Design: Retrospective review.

Setting: Large clinic referral center.

Patients: All patients admitted after outpatient liver biopsy at the Mayo Clinic from 1 April 1989 to 1 April 1991.

Results: During this period, 405 outpatients underwent biopsy. Of the 405 patients, 13 (3.2%) were admitted with complications after biopsy. Five patients (38%) were admitted with persistent localized pain, five (38%) with orthostatic hypotension, one (8%) with both pain and hypotension, one (8%) with peritoneal signs, and one (8%) with lightheadedness but no orthostatic changes. All complications were noted within 3 hours after the biopsy. Bleeding, potentially the most serious complication, was radiographically defined in 5 of the 13 patients (38%) admitted. Only two patients, however, required blood transfusions. No patient required invasive management such as surgery or chest tube placement. The average length of the hospital stay was 1.5 days.

Conclusion: Complications after outpatient liver biopsy occur early and rarely require invasive management. Outpatient liver biopsy is safe when done on carefully selected patients in a setting that provides close observation for at least 3 hours after liver biopsy.

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