Objective: To estimate the effectiveness of ovarian cancer screening with CA 125 and transvaginal sonography.
Design: Decision analysis was used to examine the no-screen compared with the screen strategy.
Setting: Estimates of cancer incidence, survival, and life expectancy were derived from population-based data and clinical series.
Subjects: A cohort of 40-year-old women of all races and residing in the United States.
Interventions: A one-time screening intervention. The criterion standard for diagnosis of ovarian cancer was evaluation with exploratory laparotomy.
Main Outcome Measure: Average years of life expectancy gained by women in the screened group.
Results: Screening for ovarian cancer with a combination of CA 125 and transvaginal sonography increases the average life expectancy in the population by less than 1 day.
Conclusions: Given the limited effect on overall life expectancy, it is unlikely that mass screening for ovarian cancer with CA 125 and transvaginal sonography would be an effective health policy.