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Is Antiretroviral Treatment after Percutaneous HIV Exposure Justified?

Julie Gerberding, MD, MPH
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San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94110. Requests for Reprints: J.L. Gerberding, MD, MPH, Medical Service 5H-22, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110.

Copyright 2004 by the American College of Physicians

Ann Intern Med. 1993;118(12):979-980. doi:10.7326/0003-4819-118-12-199306150-00012
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The practice of treating health care providers occupationally exposed to human immunodeficiency virus with zidovudine has become widespread, despite the absence of data showing treatment efficacy. We need to encourage basic and clinical research relevant to occupational exposure so that a scientific basis for postexposure use can be established. In the interim, Provision of zidovudine or other antiviral agents should be regarded as an experimental treatment option, not as a standard of care.

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