0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Non-A, Non-B Post-Transfusion Hepatitis: Looking Back in the Second Decade

Ronald L. Koretz, MD; Heather Abbey, RN; Elizabeth Coleman, RN; and Gary Gitnick, MD
[+] Article and Author Information

From the Center for Health Sciences, University of California, Los Angeles, California. Requests for Reprints: Ronald L. Koretz, MD, Department of Medicine, Olive View Medical Center, 14445 Olive View Drive, Sylmar, CA 91342. Acknowledgments: The authors thank Sally Memmott and Sylvia Anguiano for assistance in revising the manuscript and Deborah Lott for editorial assistance.


Copyright 2004 by the American College of Physicians


Ann Intern Med. 1993;119(2):110-115. doi:10.7326/0003-4819-119-2-199307150-00003
Text Size: A A A

Objective: To determine the long-term course of non-A, non-B post-transfusion hepatitis.

Design: Follow-up in 1989 to 1992 of patients prospectively identified as having contracted non-A, non-B post-transfusion hepatitis between 1972 and 1980.

Setting: A university hospital.

Patients: Patients who were prospectively followed from receipt of blood products and in whom otherwise unexplained abnormalities in their serum alanine aminotransferase levels developed without serologic evidence of exposure to hepatitis A or B.

Measurements: The presence or absence of clinical evidence of liver failure or symptoms of chronic hepatitis.

Results: Of 90 patients identified in the 1970s, 80 were recontacted and evaluated between 1989 and 1992. Based on the current status of these 80 patients and on the last known status of the remaining patients, the following observations were made: 1) Although about 40% had some symptoms during the early phase of the disease, none subsequently experienced significant clinical problems related to hepatic inflammation; 2) eight patients [seven with chronic hepatitis] developed hepatic failure; and 3) life-table analysis showed that the probabilities of developing clinical evidence of cirrhosis after 16 years of disease in the entire cohort, in the subgroup who developed chronic hepatitis, in the patients who had hepatitis C, and in those with chronic hepatitis C were 18%, 21%, 17%, and 20%, respectively.

Conclusions: For most of the study patients, non-A, non-B post-transfusion hepatitis was a biochemical and histologic disease that had not yet caused hepatic symptoms. If hepatic failure does occur, it is usually seen only after 10 or more years of disease. Before that time, many infected persons die due to other disease processes.

Figures

Grahic Jump Location
Figure 1.
Cumulative probability of clinical liver failure (closed circle) or death from nonhepatic causes (X) over time since the onset of post-transfusion hepatitis.
Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)