The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Gastric Intramural pH as a Predictor of Success or Failure in Weaning Patients from Mechanical Ventilation

Z. Mohsenifar, MD; Angela Hay, MD; Jeffrey Hay, MD; Michael I. Lewis, MD; and Spencer K. Koerner, MD
[+] Article, Author, and Disclosure Information

From Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, California. Requests for Reprints: Z. Mohsenifar, MD, Cedars-Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Boulevard Pulmonary Division, Room 6732, Los Angeles, CA 90048.

Copyright 2004 by the American College of Physicians

Ann Intern Med. 1993;119(8):794-798. doi:10.7326/0003-4819-119-8-199310150-00004
Text Size: A A A

Objective: To determine whether gastric intramural pH (pHi), an indirect measure of gastric mucosal ischemia, can be used to predict the success of weaning from mechanical ventilation. Gastric mucosal ischemia (and, therefore, acidosis) may develop in patients during unsuccessful attempts to wean them from mechanical ventilation because blood flow from nonvital areas (for example, splanchnic bed) is diverted to meet the increased demands of respiratory muscles.

Design: Cohort study.

Setting: Intensive care unit.

Patients: Twenty-nine patients receiving assisted mechanical ventilation for respiratory failure who were thought by their physicians to be weanable from mechanical ventilation.

Measurements: Simultaneous samples of arterial blood and gastric juice were obtained from patients during assisted mechanical ventilation, as well as during weaning trials. The predictor variable, pHi, was calculated using the following equation: 6.1 + log HCO3/(gastric PCO2 0.0307). The outcome was success or failure of weaning, decided by physicians blinded to the study.

Results: Patients who could not be weaned from mechanical ventilation had a substantially reduced gastric pHi (7.36 during mechanical ventilation compared with 7.09 during weaning [difference, 0.27; 95% CI, 0.12 to 0.42; P < 0.01]). Patients who were successfully weaned from mechanical ventilation showed no change in pHi (7.45 during mechanical ventilation compared with 7.46 during weaning [difference, 0.01; CI, 0.01 to 0.03; P = 0.29]). The sensitivity and specificity of pHi in predicting weaning success or failure were both 100% (CI, 81 to 100 and 72 to 100, respectively).

Conclusion: Gastrointestinal acidosis may be an early sign of weaning failure. Measurement of pHi, which is simple and rapid, may be of practical value in predicting the likelihood of weaning success or failure during weaning trials.


Grahic Jump Location
Figure 1.
Gastric intramural pH during mechanical ventilation and during weaning.nPnP

Among patients who were successfully weaned ( = 18), the mean gastric intramural pH (pHi) level did not change (7.45 during mechanical ventilation compared with 7.46 during weaning; = 0.29). Among patients in whom weaning failed ( = 11), pHi decreased from 7.36 to 7.09 ( = 0.003).

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.