The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Hydroxychloroquine Is Safe and Probably Useful in Rheumatoid Arthritis

Edward D. Harris, MD
[+] Article, Author, and Disclosure Information

Stanford University School of Medicine, Stanford, CA 94305. Requests for Reprints: Edward D. Harris, Jr., MD, Department of Medicine, Stanford University School of Medicine, Room S-102, Stanford, CA 94305-5109.

Copyright 2004 by the American College of Physicians

Ann Intern Med. 1993;119(11):1146-1147. doi:10.7326/0003-4819-119-11-199312010-00014
Text Size: A A A

The history of antimalarial drug therapy in rheumatoid arthritis has several distinct phases. The first was a fairly widespread enthusiasm for the drugs [1]. For example, Freedman and Steinberg [2] reported a definite general improvement in 85 of 107 (80%) patients who completed 1 year of chloroquine treatment, compared with 30% of the placebo group. Whereas 25% of the control patients were clinically deteriorating, only 5% of the patients treated with chloroquine lost ground during the study. This enthusiasm was fueled by the disillusionment in the 1950s with corticosteroids as a primary therapy because of the destructive toxicity of prednisone or its equivalent used in doses greater than 10 mg/d. In addition, no satisfactory, nontoxic, nonsteroidal drugs were available as a substitute for aspirin.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.