0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Dose Effects of Aspirin on Gastric Prostaglandins and Stomach Mucosal Injury

Makau Lee, MD; Byron Cryer, MD; and Mark Feldman, MD
[+] Article and Author Information

From the University of Texas Southwestern Medical Center and the Veterans Affairs Medical Center, Dallas, Texas. Requests for Reprints: Mark Feldman, MD, Medical Service (111), Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216. Acknowledgments: The authors thank Cora Barnett, Mary Walker, Dr. V. K. Pillai, and Philip Michaelson for technical assistance. Grant Support: By a merit grant from the Department of Veterans Affairs and an R01 grant from the National Institute for Diabetes, Digestive and Kidney Disease (DK16816). The study was also supported by the Southland Financial Corporation Chair in Geriatrics (MF).


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1994;120(3):184-189. doi:10.7326/0003-4819-120-3-199402010-00002
Text Size: A A A

Objective: To determine if a dose of aspirin exists that might inhibit thromboxane-dependent platelet function without causing gastric mucosal injury, we studied the effects of a wide range of doses of aspirin (3 mg/d to 2600 mg/d) on gastric juice prostaglandins (PGE2 and PGF), on serum thromboxane B2, and on stomach mucosal injury as reflected by gastric juice hemoglobin and DNA concentrations.

Design: A randomized, placebo-controlled study.

Setting: Research laboratory at a Veterans Affairs medical center.

Participants: 16 healthy volunteers (5 men and 11 women).

Intervention: In the first part of the study, volunteers received placebo; aspirin, 324 mg/d; 1300 mg/d; or 2600 mg/d for 2 days. In the second part, volunteers received placebo; aspirin, 3 mg/d; 10 mg/d; 30 mg/d; or 81 mg/d for 8 days.

Measurements: Gastric juice PGE2 and PGF, hemoglobin and DNA concentrations; gastric juice volume and acidity; and serum salicylate and thromboxane B2 concentrations.

Results: In the first part, significant and similar (approximately 50%) inhibition of gastric juice prostaglandin output was observed with daily aspirin doses of 324 to 2600 mg. However, a significant increase in gastric juice hemoglobin output occurred only with 2600 mg/d. In the second part, significant inhibition (approximately 50%) of gastric PGE2 output was noted at a daily aspirin dose of 30 mg. Lower aspirin doses did not reduce PGE2 output significantly, although these doses did significantly reduce serum thromboxane B2 in a dose-related manner.

Conclusions: Aspirin can significantly reduce serum thromboxane B2 at doses of 3 mg/d or 10 mg/d, which are significantly below the threshold dose for significant gastric prostaglandin inhibition and acute stomach mucosal injury.

Figures

Grahic Jump Location
Figure 1.
Effects of aspirin dose on gastric juice outputs.22P

Results are expressed as a mean percent change from placebo for nine volunteers, with 95% CIs. Mean (±SE) outputs for the zero dose (placebo) were 108.9 ± 25.0 ng/h (PGE ); 56.1 ±9.4 ng/h (PGF α); 16.7 ± 5.6 mg/h (hemoglobin); and 436.4 ±130.8 µg/h (DNA). * < 0.05 compared with placebo.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Effects of aspirin dose on serum thromboxane B2 and gastric juice outputs.2222P

Results are expressed as a mean percent change from placebo for nine volunteers, with 95% CIs. Mean (±SE) outputs for the zero dose (placebo) were 700 ±60.9 ng/mL (serum thromboxane B [TxB ]); 78.4 ±16.9 ng/h (PGE ); 30.9 ±8.5 ng/h (PGF α); 7.4 ±1.4 mg/h (hemoglobin); and 885.6 ±137.2 µg/h (DNA). * < 0.05 compared with placebo.

Grahic Jump Location
Grahic Jump Location
Figure 3.
Dose-related inhibitory effects of aspirin on serum thromboxane B2 and gastric juice PGE2 outputs.2222P2

Percent change was calculated for each participant compared with his or her own control value. Each data point represents the mean percent change with 95% CI. ▵ = thromboxane B (TxB ) data from part 2; closed circle = gastric juice prostaglandin (PGE ) data from part 1; ○ = PGE data from part 2. * < 0.05 compared with the PGE curve.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)