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Peripheral Facial Nerve Palsy after High-Dose Radioiodine Therapy in Patients with Papillary Thyroid Carcinoma

David Levenson, MD; Seza Gulec, MD; Martin Sonenberg, MD, PhD; Eseng Lai, MD, PhD; Stanley J. Goldsmith, MD; and Steven M. Larson, MD
[+] Article, Author, and Disclosure Information

From the Memorial Sloan-Kettering Cancer Center, New York, New York. Requests for Reprints: David Levenson, MD, Department of Medicine, Endocrinology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6094. Grant Support: By the Endocrine and Metabolic Research Training Program, National Institutes of Health grant DK07313.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;120(7):576-578. doi:10.7326/0003-4819-120-7-199404010-00008
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Sialoadenitis is a frequent complication of radioiodine treatment, occurring clinically in 10% of patients [1], although biochemical alterations of saliva are present 100% of the time [2]. This is caused by the similar iodine avidity of the salivary gland and thyroid tissue, each achieving a tissue-to-serum ratio of approximately 50 [3]. Administration of thyroid-stimulating hormone can cause a tenfold increase in thyroid iodine uptake [4].

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Figure 1.
Diagnostic and posttherapy radioiodine scans.topbottomleftright

Twenty-four-hour scans after the diagnostic (74 MBq or 2 mCi) dose ( ) and posttherapy scans ( ). Note the intense uptake in the region of the parotids in patient 1 ( ) compared with the more moderate uptake in patient 2 ( ).

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