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Calcium Antagonist-Induced Gingival Hyperplasia

Ruth M. Steele, PharmD; Arthur A. Schuna, MS, RPh; and Ronald T. Schreiber, MD
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From William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin. Requests for Reprints: Ruth M. Steele, PharmD, Department of Pharmacy, Cook County Hospital, 1900 West Polk, Suite 552, Chicago, IL 60612. Acknowledgments: The authors thank John Tsunehiro, DDS, William Ricks, DDS, and Greg Paprocki, DDS, of the Department of Dentistry at William S. Middleton Memorial Veterans Hospital for their technical support and the Department of Veterans Affairs Research Service for editorial assistance.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;120(8):663-664. doi:10.7326/0003-4819-120-8-199404150-00006
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The use of calcium antagonists has been associated with gingival tissue overgrowth [12], with reported prevalences varying as follows: 0.5% to 83% for nifedipine [34], 74% for diltiazem [3], and 4% for verapamil [5].

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