The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Thrombolytic Agents: The Science of the Art of Choosing the Better Treatment

Michael E. Farkouh, MD; Jeff D. Lang, MD; and David L. Sackett, MD, MSc
[+] Article, Author, and Disclosure Information

Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. Requests for Reprints: David L. Sackett, MD, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 5, Headington, Oxford OX3 9DU, United Kingdom.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;120(10):886-888. doi:10.7326/0003-4819-120-10-199405150-00011
Text Size: A A A

The current dispute about whether the thrombolytic agent of choice for patients with suspected heart attacks should be tissue plasminogen activator (tPA) or streptokinase is succulent. It invokes arguments across the spectrum of health research, from bench to bedside to cost–benefit. Its combatants (and many of their defenders and detractors) are informed, articulate, and proud. The financial stakes are colossal. Reputations and fortunes are on the line. There is enough science and show-biz for every interest and taste. Somewhere, William Osler and H. L. Mencken are exchanging winks.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.