The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Refractory Prinzmetal Angina Treated with Cyproheptadine

Alison D. Schecter, MD; James H. Chesebro, MD; and Valentin Fuster, MD, PhD
[+] Article, Author, and Disclosure Information

From Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts. Requests for Reprints: Valentin Fuster, MD, PhD, Cardiovascular Institute, Mount Sinai Medical Center, Box 1030, One Gustave Levy Place, New York, NY 10029. Acknowledgments: The authors thank Dr. Arthur Kennish for help in preparing this report.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;121(2):113-114. doi:10.7326/0003-4819-121-2-199407150-00006
Text Size: A A A

Serotonin, 5-hydroxytryptamine, is an important modulator of coronary vascular tone [1]. It is avidly taken up from the plasma by platelets, stored in dense granules, and released during platelet aggregation and activation. Serotonin causes vasodilatation in normal coronary arteries and mild vasoconstriction in patients with stable angina. In patients with Prinzmetal or variant angina (a syndrome of chest pain at rest associated with ST elevation), serotonin at physiologic concentrations causes an exaggerated response of occlusive vasospasm [2]. We successfully treated two patients who had documented severe refractory variant angina with cyproheptadine (Periactin; Merck & Co., West Point, Pennsylvania), a nonselective serotonergic antagonist.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Prinzmetal angina and cyproheptadine. Ann Intern Med 1995;122(2):155.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.