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Eradication of Hepatitis C Virus RNA after Alpha-Interferon Therapy

Raffaella Romeo, MD; Stanislas Pol, MD, PhD; Pierre Berthelot, MD; and Christian Brechot, MD, PhD
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From the University of Milan, Milan, Italy and Centre Hopitalier Universitaire Necker, Paris, France. Requests for Reprints: Raffaella Romeo, MD, Institute of Internal Medicine, University of Milan, via Pace, 9-20122 Milan, Italy. Grant Support: By Institut National de la Sante et Recherche Medicale, Caisse National Assurance Maladie, Association pour la Recherche contre le Cancer, and the European Community. Dr. Romeo is the recipient of a fellowship from Istituto Superiore di Sanita, Rome, Italy.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;121(4):276-277. doi:10.7326/0003-4819-121-4-199408150-00008
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Hepatitis C virus (HCV) is the main cause of chronic non-A, non-B hepatitis developing after transfusion [1]; many patients (50% to 60%) become chronic carriers, of whom as many as 20% develop cirrhosis. In approximately 25% of patients, referred to as long-term responders, α-interferon therapy can lead to a sustained and complete normalization of aminotransferase activity. The remaining patients either do not respond or relapse during or shortly after treatment [2].

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