The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Equilibration of Hemoglobin Concentration after Transfusion in Medical Inpatients Not Actively Bleeding

Andrew R. Wiesen, MD; Duane R. Hospenthal, MD, PhD; John C. Byrd, MD; Kevin L. Glass, MD; Robin S. Howard, MA; and Louis F. Diehl, MD
[+] Article, Author, and Disclosure Information

From the Walter Reed Army Medical Center, Washington, D.C. Requests for Reprints: Andrew R. Wiesen, MD, Internal Medicine Clinic, Lister Army Community Hospital, Ft. Rucker, AL 36362.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;121(4):278-280. doi:10.7326/0003-4819-121-4-199408150-00009
Text Size: A A A

More than 12 million units of packed erythrocytes are transfused annually [12]. Because blood products became widely used after World War II, hundreds of millions of units have been given [14]. Major textbooks state that an increase of 10 g/L (1 g/dL) of hemoglobin is expected per unit of blood transfused [510]. Authors [5, 8, 11] have implied that after transfusion, the rate at which the hemoglobin concentration equilibrates takes about 24 hours, but the supporting evidence is scant. The ability to rapidly determine the increase in hemoglobin levels after transfusion is important in managing outpatients and acutely ill patients. A standard time to measure the hemoglobin levels would save unnecessary blood draws.

First Page Preview

View Large
First page PDF preview


Grahic Jump Location
Figure 1.
Increase in hemoglobin concentration after transfusion.P

The increase in hemoglobin concentration after a 2-unit transfusion of packed erythrocytes was 20 ±2 g/L ( < 0.001). Values are expressed as mean ±SE; error bars represent the SE.

Grahic Jump Location
Grahic Jump Location
Figure 2.
Change in hemoglobin concentration over time.

Differences in hemoglobin concentrations between 24 hours after transfusion and 15 minutes, 1 hour, and 2 hours after a 2-unit transfusion of packed erythrocytes.

Grahic Jump Location




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.