The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Aseptic Meningitis and Intravenous Immunoglobulin Therapy

Curtis L. Scribner, MD; Richard M. Kapit, MD; Evelyne T. Phillips, RPH, MA; and Nathaniel M. Rickles, BS
[+] Article, Author, and Disclosure Information

Food and Drug Administration, Rockville; MD 20852 Requests for Reprints: Curtis L. Scribner, MD, Office of Blood Research and Review, Food and Drug Administration, HFM-370, 1401 Rockville Pike, Rockville, MD 20852-1448.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;121(4):305-306. doi:10.7326/0003-4819-121-4-199408150-00014
Text Size: A A A

Immunoglobulin fractionated from human plasma and specifically manufactured for intravenous use has been approved by the Food and Drug Administration (FDA) for many indications. From Nolte and colleagues' original 1979 report [1] showing the usefulness of this therapy in treating primary immunodeficiencies to Imbach and coworkers' study [23] showing the efficacy of the therapy compared with that of corticosteroids in the treatment of idiopathic thrombocytopenic purpura, licensed indications have been expanded to include the treatment of Kawasaki disease and the prevention of bacterial infections in persons with chronic lymphocytic leukemia. Most recently, as noted by Sekul and colleagues in this issue [4], very high doses of intravenous immunoglobulin (2 g/kg of body weight) are now being studied as a way to modulate many autoimmune diseases.

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.