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An Outbreak of Fatal Fluoride Intoxication in a Long-Term Hemodialysis Unit

Paul M. Arnow; Lee A. Bland; Sylvia Garcia-Houchins; Scott Fridkin; and Susan K. Fellner
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From the University of Chicago Hospital, Chicago, Illinois; the Centers for Disease Control and Prevention, Atlanta, Georgia. Requests for Reprints: Paul Arnow, MD, Department of Medicine (MC 5065), University of Chicago Hospital, 5841 South Maryland Avenue, Chicago, IL 60637. Acknowledgments: The authors thank Drs. Frederic Coe, Craig January, Yasushi Nakagawa, and Jerome Tokars for their helpful contributions to this investigation and Dr. Ronald Thisted for statistical advice.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1994;121(5):339-344. doi:10.7326/0003-4819-121-5-199409010-00005
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Objective: To determine the cause of an outbreak of acute illness and death in a long-term hemodialysis unit.

Design: A retrospective cohort and case–control study of patients receiving hemodialysis and a laboratory study of a model deionization system to purify water for hemodialysis.

Setting: An outpatient hemodialysis unit of a university hospital.

Patients: 12 patients who became severely ill after hemodialysis treatment and 20 patients who did not become ill after receiving hemodialysis treatment in the same unit.

Measurements: Medical and dialysis unit records were reviewed to identify and characterize cases. Fluids for dialysis were tested for toxic substances, and fluoride was measured in patients' serum. Resistivity and fluoride were measured in effluent from a model deionization system operated in the same way as the system associated with illness.

Results: During five consecutive hemodialysis shifts, 12 of 15 patients receiving dialysis treatment in one room became acutely ill, with severe pruritus, multiple nonspecific symptoms, and/or fatal ventricular fibrillation (3 patients). None of 17 patients treated in the adjacent room became ill (P < 0.0001). Death was associated with longer hemodialysis time and increased age compared with other patients who became ill. Serum concentrations of fluoride in the sick patients were markedly increased to as high as 716 µmol/L, and the source of fluoride was the temporary deionization system used to purify water for hemodialysis only in the affected room. Operation of a model deionization system showed how fluoride was adsorbed and then displaced in a massive efflux.

Conclusions: Because deionization systems are used widely in hemodialysis and can cause fatal fluoride intoxication, careful design and monitoring are essential.

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