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Isoniazid-Induced Acute Pancreatitis

Alfredo A. Rabassa, MD; Gary Trey, MD; Urmil Shukla, MD; Tobias Samo, MD; and Bhupinderjit S. Anand, MD
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From Baylor College of Medicine, Houston, Texas. Requests for Reprints: Bhupinderjit S. Anand, MD, Gastroenterology Section, Smith Tower, 6550 Fannin, SM 1122, Houston, TX 77030.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1994;121(6):433-434. doi:10.7326/0003-4819-121-6-199409150-00007
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In recent years, a resurgence of Mycobacterium tuberculosis has occurred in the United States [1], resulting in a marked increase in the use of antituberculous drugs. Isoniazid is a first-line drug in the treatment of tuberculosis and is increasingly being used as a chemoprophylactic agent. Severe adverse reactions with isoniazid have been observed; these include hepatitis, peripheral neuropathy, skin rashes, neurologic disturbances, and hematologic alterations [23]. We describe a patient with the first well-documented case of isoniazid-induced acute pancreatitis.

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