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Pituitary Tumor Hemorrhage in Cushing Disease

Leilani B. Mercado-Asis, MD, PhD; Edward H. Oldfield, MD; and Gordon B. Cutler, MD
[+] Article and Author Information

From the National Institutes of Health, Bethesda, Maryland. Requests for Reprints: Leilani B. Mercado-Asis, MD, PhD, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, 10N262, Bethesda, MD 20892.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1995;122(3):189-190. doi:10.7326/0003-4819-122-3-199502010-00006
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Spontaneous pituitary hemorrhage and necrosis (pituitary apoplexy) have been reported to occur in 9.5% to 16.6% of pituitary tumors [13]. However, pituitary apoplexy rarely develops in patients with Cushing disease. The clinical presentation of pituitary hemorrhage varies from no symptoms to a neurosurgical emergency in which structures in the sellar and parasellar regions are compressed [13]. Transient hypopituitarism is common after pituitary apoplexy. Pituitary function may improve either spontaneously [45] or after surgical decompression [67].

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