The full content of Annals is available to subscribers

Subscribe/Learn More  >
Ideas and Opinions |

Host-Directed and Immune-Based Therapies for Human Immunodeficiency Virus Infection

Michael M. Lederman, MD
[+] Article, Author, and Disclosure Information

From the AIDS Clinical Trials Unit, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio. Requests for Reprints: Michael M. Lederman, MD, Department of Medicine/Division of Infectious Diseases, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106. Acknowledgments: The author thanks Drs. Jerrold Ellner, Jonathan Kagan, Norman Letvin, and Robert Schooley for their thoughtful comments. Grant Support: By the National Institutes of Health (AI 25879).

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;122(3):218-222. doi:10.7326/0003-4819-122-3-199502010-00010
Text Size: A A A

This essay reviews the rationale underlying host-directed or immune-based therapeutic strategies for human immunodeficiency virus (HIV) infection and its complications. These approaches have seen only limited trial in the past 10 years, but as more is learned about the immunopathogenesis of HIV disease and as the limitations of virus-directed therapies become more apparent, the need to pursue other therapeutic avenues has become increasingly important. Moreover, properly designed trials of host-directed and immune-based therapies can provide key insights into the pathogenesis of HIV disease that may be otherwise unattainable through in vitro studies.


hiv infection





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.