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Hepatitis C Genotypes: The Key to Pathogenicity?

Paul Martin, MD
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University of California at Los Angeles, Los Angeles, CA 90024 Requests for Reprints: Paul Martin, MD, Division of Digestive Diseases, Center for the Health Sciences, University of California at Los Angeles, Los Angeles, CA 90024. Acknowledgments: The author thanks Judy Grimes for excellent secretarial help and Johnson Y.N. Lau, MD, for helpful suggestions.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;122(3):227-228. doi:10.7326/0003-4819-122-3-199502010-00012
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Although investigation of the hepatitis C virus (HCV) has proceeded rapidly since the virus was discovered, numerous important issues about HCV, including the risk for disease progression in patients with chronic HCV infection and the role of interferon therapy, require clarification. This discussion focuses on predictors of both disease progression and response to interferon therapy; in particular, it considers the ways in which new research on HCV genotypes may shed light on these important and unresolved questions.

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