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Living Related-Donor Liver Transplantation from Adult to Adult for Primary Biliary Cirrhosis

Takafumi Ichida, MD; Hidetoshi Matsunami, MD; Seiji Kawasaki, MD; Masatoshi Makuuchi, MD; Takeshi Harada, MD; Shinichi Itoh, MD; and Hitoshi Asakura, MD
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From the Niigata University School of Medicine, Niigata City, Japan; and the Shinsyu University School of Medicine, Nagano, Japan. Requests for Reprints: Takafumi Ichida, MD, Third Department of Internal Medicine, Niigata University School of Medicine, 754 Asahimachi-Dori 1, Niigata City, Niigata Japan 951. Grant Support: In part by the Vehicle Racing Commemorative Foundation for the Program of Japanese Survey for the Liver Transplantation.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1995;122(4):275-276. doi:10.7326/0003-4819-122-4-199502150-00006
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The shortage of donor cadaveric organs necessitates a continued search for additional options in the treatment of primary biliary cirrhosis, options such as liver xenograft [1] and living related-donor (LRD) liver transplantation [2]. The potential benefit of liver xenograft remains unclear because the procedure has many unresolved immunologic problems [3]. In contrast, LRD liver transplantation can realistically be used to resolve the problems of inadequate pediatric and urgent adult transplantation [4]. For pediatric LRD liver transplantation, a sufficient volume of parental liver can be harvested to guarantee the survival of the pediatric recipient. However, the clinical outcome of LRD liver transplantation done from adult to adult depends on regeneration of the donor liver [5]. We describe an LRD liver transplantation that was done in a 53-year-old woman with primary biliary cirrhosis using a partial liver graft obtained from the woman's 25-year-old son.

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Figure 1.
Computed tomographic scans of donor and recipient after living related-donor liver transplantation.

1) Donor's liver, 404 mg of left lobe; 2) 900-mL liver volume 17 days after transplantation; 3) 1150-mL liver volume 1 month after transplantation; and 4) 1250-mL liver volume 3 months after liver transplantation.

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