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Clinical Remission after Syngeneic Bone Marrow Transplantation in a Patient with AL Amyloidosis

Marjolein van Buren, MD; Ronald J. Hene, MD; Leo F. Verdonck, MD; Fred J. Verzijlbergen, MD; and Henk M. Lokhorst, MD
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From the University Hospital Utrecht, Utrecht, the Netherlands. Requests for Reprints: Henk M. Lokhorst, MD, Department of Hematology, University Hospital Utrecht (G03.647), Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;122(7):508-510. doi:10.7326/0003-4819-122-7-199504010-00005
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Systemic amyloidosis is characterized by accumulation of an eosinophilic amorphous material. Two proteins compose the deposits, one of which is the α-glycoprotein amyloid P. The nature of the other protein depends on the underlying cause of the illness (light chains in cases of AL amyloidosis associated with monoclonal gammopathy or amyloid A in cases of AA amyloidosis associated with chronic inflammatory disease).

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Grahic Jump Location
Figure 1.
Investigation before and 2 years after bone marrow transplantation.Top.Bottom.

Abdominal anterior view 24 hours after injection of Iodine-123-labeled serum albumin precursor. The uptake in the spleen is high; uptake in the liver is slightly lower. There is scarcely any background activity. Abdominal anterior view 24 hours after injection of Iodine-123-labeled serum amyloid precursor. A pronounced background (heart and blood vessels), shows the lower uptake in all tissues. Activity in spleen, liver, and kidneys (which are now visible because of the lower level of activity in the spleen and the liver) is about equal. Abbreviations: H = heart; K = kidney; L = liver; S = spleen.

Grahic Jump Location




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