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When Hormones Fail To Act

Clark T. Sawin, MD
[+] Article and Author Information

Boston Veterans Affairs Medical Center Boston, MA 02146 Requests for Reprints: Clark T. Sawin, MD, Boston Veterans Affairs Medical Center, 150 South Huntington Avenue, Boston, MA 02146.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1995;123(8):625-627. doi:10.7326/0003-4819-123-8-199510150-00010
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In this issue, Brucker-Davis and colleagues [1] give us a better definition of resistance to thyroid hormone. Most of the patients in their study had the attention-deficit hyperactivity disorder, and many had an IQ that was lower than expected. All had elevated serum thyroid hormone levels, although the variation was wide. Interestingly, most had serum thyroid-stimulating hormone concentrations within the normal range; furthermore, pulse and basal metabolic rates were about the same in patients and controls. Few patients were overtly hypothyroid or hyperthyroid, but most had some features of these states.

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