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Predicting Progression to AIDS

Warner C. Greene, MD, PhD
[+] Article, Author, and Disclosure Information

Gladstone Institute of Virology and Immunology University of California, San Francisco San Francisco, CA 94141 Acknowledgments: The author thanks Drs. J.M. McCune and J. Kahn for helpful discussions. Requests for Reprints: Warner C. Greene, MD, PhD, Gladstone Institute of Virology and Immunology, P.O. Box 419100, 1310A Potrero Avenue, San Francisco, CA 94110.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;123(9):726-727. doi:10.7326/0003-4819-123-9-199511010-00013
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Whom to treat, when to treat, and how to treat? These are the difficult questions faced all too frequently by clinicians caring for persons with human immunodeficiency virus (HIV) infection. Now, nearly 15 years into the expanding acquired immunodeficiency syndrome (AIDS) epidemic, we understand that HIV may produce distinctly different temporal patterns of disease progression in different persons [12]. We also appreciate that the current pharmacopoeia of anti-HIV drugs is distinguished as much by its toxicity and its potential to induce drug resistance as it is by its long-term therapeutic benefit [3]. Consequently, many physicians have turned to a more individualized, “patient-specific” approach to treatment.

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