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Diabetes, Fish Oil, and Vascular Disease

William E. Connor, MD
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From Oregon Health Sciences University Portland, OR 97201. Requests for Reprints: William E. Connor, MD, Department of Medicine, L465, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;123(12):950-952. doi:10.7326/0003-4819-123-12-199512150-00010
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The major cause of death in patients with diabetes mellitus is macrovascular disease, particularly coronary heart disease, stroke, and atherosclerosis of the lower extremities. Indeed, the incidence of these ischemic complications is 1.7 to 4 times greater in men with diabetes than in men without diabetes and is 2.7 to 6.4 times greater in women with diabetes than in women without diabetes [1]. The presence of diabetes even eliminates the usual protection from coronary disease that premenopausal women have compared with men of similar age. Diabetic persons of either sex have had a two- to four-fold increase in mortality in population studies done throughout the world [2]. The development of atherosclerosis is greatly accelerated in persons with diabetes [3].

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