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Normalization of Intracellular Calcium: A Sweet Solution to Neutrophil Dysfunction in Diabetes?

Matthew Bidwell Goetz, MD, FACP; and Richard A. Proctor, MD, FACP
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From West Los Angeles Veterans Affairs Medical Center, UCLA School of Medicine, Los Angeles, CA 90073University of Wisconsin Medical School, Madison, WI 53696. Requests for Reprints: Matthew Bidwell Goetz, MD, Chief, Infectious Diseases, West Los Angeles Veterans Affairs Medical Center (111F), 11301 Wilshire Boulevard, Los Angeles, CA 90073.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1995;123(12):952-954. doi:10.7326/0003-4819-123-12-199512150-00011
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The diapedesis of the white corpuscles, their migration through the vessel wall into the tissues, is one of the principal means of defense possessed by the animal.As soon as the infective agents have penetrated into the body, a whole army of white corpuscles proceed towards the menaced spot, there entering into a struggle with the microorganisms.… The leukocytes, having arrived at the spot where the intruders are found, seize them after the manner of Amoebae and within their bodies subject them to intracellular digestion.

Ilya I'litch Metchnikoff (1882)

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