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γδ T Cells in Asthma

Milton D. Rossman, MD; and Simon R. Carding, MD
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University of Pennsylvania School of Medicine Philadelphia, PA 19104 Grant Support: By NIH grant HL-51749. Request for Reprints: Milton D. Rossman, MD, Pulmonary and Critical Care, Room 814 East Gates Building, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;124(2):266-267. doi:10.7326/0003-4819-124-2-199601150-00013
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In this issue of Annals, Spinozzi and colleagues [1] report their observations on γδ T cells in the lungs of asthmatic patients. This is the first report of increased γδ T cells in the bronchoalveolar fluid from patients with asthma. Although they did not detect any γδ T cells in samples from the lungs of their controls or from patients with sarcoidosis, extrinsic allergic alveolitis, cystic fibrosis, or anatomic malformations of the airways, the finding of increased γδ T cells in the blood or in lung samples in patients with sarcoidosis and extrinsic allergic alveolitis has been previously reported [24]. Nevertheless, the finding of increased T cells in patients with asthma raises questions about the nature of these cells and their potential role in asthma.


asthma ; t-lymphocyte

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