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Prophylaxis for HIV-Related Infections: A Work in Progress

William G. Powderly, MD, FRCPI
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Washington University School of Medicine St. Louis, MO 63108 Grant Support: In part by grant AI-25903 from the National Institutes of Health. Requests for Reprints: William Powderly, MD, AIDS Clinical Trials Unit, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;124(3):342-344. doi:10.7326/0003-4819-124-3-199602010-00012
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Although promising recent advances have been made in antiretroviral therapy, human immunodeficiency virus (HIV) infection remains a lethal problem for infected patients. Opportunistic infections are clearly the most important complication of HIV infection, and they cause considerable morbidity and mortality. Prophylaxis for Pneumocystis carinii pneumonia has been standard care in HIV therapeutics for almost a decade, and the result of this has been increased survival and delay in the onset of other illnesses related to the acquired immunodeficiency syndrome (AIDS) [1]. In the last year, the results of clinical trials showing effective prophylaxis for the most common HIV-related opportunistic infections—systemic fungal, Mycobacterium avium complex, and cytomegalovirus—have been announced, resulting in a dramatic potential to alter the nature of advanced HIV infection.



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