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USPHS/IDSA Guidelines for the Prevention of Opportunistic Infections in Persons Infected with Human Immunodeficiency Virus: A Summary

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Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;124(3):349-361. doi:10.7326/0003-4819-124-3-199602010-00016
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In the United States, opportunistic infections reduce the quality and duration of life for approximately 1 million persons who have HIV infection [1], especially for the estimated 250,000 persons who are severely immunosuppressed, as measured by a CD4+ T-lymphocyte count below 200 cells/µL ((2); Centers for Disease Control [CDC], unpublished data). In the late 1980s and early 1990s, efforts to prevent opportunistic infections focused first on chemoprophylaxis against Pneumocystis carinii pneumonia (PCP) [34], and then on chemoprophylaxis against disseminated Mycobacterium avium complex (MAC) disease [5].

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