The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

The Quality of Drug Studies Published in Symposium Proceedings

Mildred K. Cho, PhD; and Lisa A. Bero, PhD
[+] Article, Author, and Disclosure Information

From the University of Pennsylvania, Philadelphia, Pennsylvania; and the University of California, San Francisco, California. Acknowledgments: The authors thank their reviewers Anu Banerjee, MD, Steve Deputy, MD, Piero Gepetti, MD, Saba Masho, MD, MPH, Haim Mayan, MD, Barry Rotman, MD, Daniel Stryer, MD, and Leah Vaughan, MD, MPH, for their time and effort. Grant Support: In part by the American Association for Retired Persons, the Cigarette and Tobacco Surtax Fund of the State of California through the Tobacco-Related Disease Research Program of the University of California (award 4RT0035), the Pew Charitable Trusts, and the Veterans Affairs Office of Academic Affairs and Health Services Research and Development Service Research Funds. Requests for Reprints: Mildred K. Cho, PhD, University of Pennsylvania Center for Bioethics, 3401 Market Street, Suite 320, Philadelphia, PA 19104-3308. Current Author Addresses: Dr. Cho: University of Pennsylvania Center for Bioethics, 3401 Market Street, Suite 320, Philadelphia, PA 19104-3308.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;124(5):485-489. doi:10.7326/0003-4819-124-5-199603010-00004
Text Size: A A A

Objective: To compare the quality, relevance, and structure of drug studies published in symposium proceedings that are sponsored by drug companies with 1) articles from symposia with other sponsors and 2) articles in the peer-reviewed parent journals of symposium proceedings; and to study the relation between drug company sponsorship and study outcome.

Design: Cross-sectional studies of clinical drug studies published in symposium proceedings or their parent medical journals.

Measurements: The proportion of articles with no methods sections (which are necessary to assess quality); methodologic quality and clinical relevance scores; and the proportion of articles with outcomes favoring the drug of interest.

Results: Symposia sponsored by single drug companies had more articles without methods sections (10%; 108 of 1064) than did symposia that had other sponsors (3%; 58 of 2314) or symposia that had no mentioned sponsor (2%; 29 of 1663) (P < 0.001). The mean methodologic quality and relevance scores of articles were similar both by type of sponsorship and between articles published in symposia sponsored by single drug companies and articles from the parent journals. Significantly more articles with drug company support (98%; 39 of 40) than without drug company support (79%; 89 of 112) had outcomes favoring the drug of interest (P = 0.01).

Conclusions: Articles in symposia sponsored by single drug companies were similar in quality and clinical relevance to articles with other sponsors and to articles published in the parent journals. Articles with drug company support are more likely than articles without drug company support to have outcomes favoring the drug of interest.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.