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Association between the DRB1*08032 Histocompatibility Antigen and Methimazole-Induced Agranulocytosis in Japanese Patients with Graves Disease

Hajime Tamai, MD; Tohru Sudo, MD; Akinori Kimura, MD; Toshio Mukuta, MD; Sunao Matsubayashi, MD; Kanji Kuma, MD; Shigenobu Nagataki, MD; and Takehiko Sasazuki, MD
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From Kyushu University, Fukuoka, Japan; Tokyo Medical and Dental University, Tokyo, Japan; Kuma Hospital, Kobe, Japan; and Nagasaki University School of Medicine, Nagasaki, Japan. Grant Support: In part by the Ministry of Education, Culture, and Science, Japan; the Ministry of Health and Welfare, Japan; and the Naito Foundation. Requests for Reprints: Hajime Tamai, MD, Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan. Current Author Addresses: Drs. Tamai, Mukuta, and Matsubayashi: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;124(5):490-494. doi:10.7326/0003-4819-124-5-199603010-00005
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Objective: To determine the association between HLA class II genes and methimazole-induced agranulocytosis in patients with Graves disease.

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