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Successful Treatment of Behcet Disease with Pentoxifylline

Kozo Yasui, MD; Kouichi Ohta, MD; Masakazu Kobayashi, MD; Toru Aizawa, MD; and Atsushi Komiyama, MD
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Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1996;124(10):891-893. doi:10.7326/0003-4819-124-10-199605150-00005
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Behcet disease is a chronic condition that is common in Japan and the countries on the Mediterranean Sea. Its cause is still unknown, but its occurrence is strongly associated with HLA-B51 antigen. Neutrophil motility and superoxide production are characteristically increased in patients with Behcet disease.

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Figure 1.
Clinical course of patient 3.

Pentoxifylline therapy was started at 600 mg/d on 27 April 1995 and was reduced to 300 mg/d 2 weeks later. This therapy alleviated the patient's oral ulcers and iridocyclitis and decreased his C-reactive protein concentration and body temperature. Other symptoms, including hypopyon and folliculitis, also disappeared with this treatment.

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Figure 2.
Effect of pentoxifylline treatment on production of superoxide by neutrophils stimulated with n-formylmethionyl-leucylphenylalanine (1 µmol/L).n

Before equals before administration of pentoxifylline; during equals 2 weeks after the start of pentoxifylline therapy. Values are the average of measurements obtained on three samples for each patient. The shaded area denotes the mean ±SD of controls ( = 10).

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