0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Protease Inhibitors for HIV Infection

John G. Bartlett, MD
[+] Article and Author Information

Johns Hopkins University School of Medicine, Baltimore, MD 21205.. Requests for Reprints: John G. Bartlett, MD, Ross 1159, 720 Rutland Avenue, Baltimore, MD 20205.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1996;124(12):1086-1088. doi:10.7326/0003-4819-124-12-199606150-00011
Text Size: A A A

Antiviral therapy directed against human immunodeficiency virus type 1 (HIV-1) is now approaching its 10-year anniversary. The initial clinical trial of zidovudine was completed in September 1986, and, with expedited review, zidovudine was approved by the Food and Drug Administration (FDA) early in 1987 [1]. The ensuing years have seen the introduction of many other nucleoside analogues that inhibit reverse transcriptase, including (in order of their approval by the FDA) didanosine, zalcitabine, stavudine, and lamivudine. All of these drugs inhibit HIV in vitro, all are associated with a decrease in viral RNA concentrations in serum, all are associated with an increase in CD4 cell counts, and four of the five are known to reduce rates of progression to the acquired immunodeficiency syndrome (AIDS) or prolong survival, or both. The principal problems of these drugs are their limited antiviral activity, their toxicity, and their lack of a durable antiviral effect, which is at least partly explained by the development of resistance. The result is what has come to be called a “time-limited benefit,” which has provoked substantial controversy about the relative merits of early and late initiation of treatment.

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)