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Formation of Antibodies to Factor VIII in Patients with Hemophilia A Who Are Treated with Interferon for Chronic Hepatitis C

Eveline P. Mauser-Bunschoten, MD, PhD; Marjolein Damen, MD; Henk W. Reesink, MD, PhD; Goris Roosendaal, MD; Robert A.F.M. Chamuleau, MD, PhD; and H. Marijke van den Berg, MD, PhD
[+] Article and Author Information

From University Hospital Utrecht and Wilhelmina Children's Hospital, Utrecht, the Netherlands; and Red Cross Blood Bank, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Academic Medical Center, Amsterdam, the Netherlands. Requests for Reprints: Eveline P. Mauser-Bunschoten, MD, PhD, Van Creveld Clinic, University Hospital Utrecht, Postbox 85500, 3508 AG Utrecht, the Netherlands. Current Author Addresses: Drs. Mauser-Bunschoten, Roosendaal, and van den Berg: Van Creveld Clinic, University Hospital Utrecht, Postbox 85500, 3508 AG Utrecht, the Netherlands.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1996;125(4):297-299. doi:10.7326/0003-4819-125-4-199608150-00007
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Objective: To evaluate the risk for development of antibodies to factor VIII (factor VIII inhibitors) during and after interferon therapy in patients with hemophilia A and chronic hepatitis C infection.

Design: Patients were divided into two treatment groups and an untreated control group. Test results from the two treatment groups were compared with those from the control group.

Setting: 3 clinical centers in the Netherlands.

Patients: 35 men with hemophilia A who had acquired hepatitis C through the use of plasma-derived clotting factor concentrates.

Measurements: Patients were tested for factor VIII inhibitors before the start of interferon therapy and every 6 months thereafter.

Results: 21 patients with hemophilia A received interferon therapy for chronic hepatitis C infection for a mean of 19.5 months (range, 0.5 to 36 months). In 2 patients, inhibitors were detected on one occasion (maximum titer, 1.2 Bethesda units/mL) during interferon therapy. In 3 patients who were known to have had inhibitors before interferon therapy, no anamnestic reaction was seen during treatment. In 3 of 14 untreated controls who were followed for a mean of 28 months (range, 18 to 40 months), inhibitors were detected on one occasion (maximum titer, 2.3 Bethesda units/mL).

Conclusion: Long-term interferon therapy in patients with hemophilia did not increase the risk for development of factor VIII inhibitors.

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