0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Relation between Intake of Flavonoids and Risk for Coronary Heart Disease in Male Health Professionals

Eric B. Rimm, ScD; Martijn B. Katan, PhD; Alberto Ascherio, MD; Meir J. Stampfer, MD; and Walter C. Willett, MD
[+] Article and Author Information

From Harvard School of Public Health, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts; and Agricultural University, Wageningen, the Netherlands. Acknowledgments: The authors thank the participants of the Health Professionals Follow-up Study for their continued cooperation and participation; Jeanne de Vries and Peter Hollman for food analyses; Al Wing, Laura Sampson, Susan Woo, Mira Kaufman, and Steve Stuart for computer assistance; and Jill Arnold, Betsy Frost-Hawes, Kerry Pillsworth, and Mitzi Wolff for assistance with data compilation and manuscript preparation. Requests for Reprints: Eric Rimm, ScD, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115. Current Author Addresses: Drs. Rimm, Ascherio, and Willett: Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1996;125(5):384-389. doi:10.7326/0003-4819-125-5-199609010-00005
Text Size: A A A

Objective: Flavonols and flavones are subgroups of flavonoids and are found in tea, vegetables, fruits, and red wine. Because they have antioxidant properties, we investigated whether intake of these dietary compounds is associated with a lower risk for fatal and nonfatal coronary heart disease.

Design: Prospective cohort study.

Setting: United States.

Patients: 34 789 male health professionals, 40 to 75 years of age, who responded to a questionnaire in 1986.

Measurements: In 1986 and 1990, detailed, 131-item questionnaires were used to assess dietary intake of flavonols and flavones.

Results: Between 1986 and 1992, 496 patients received a new diagnosis of nonfatal myocardial infarction. The relative risk for nonfatal myocardial infarction was 1.08 (95% CI, 0.81 to 1.43) for the highest (median, 40.0 mg/d) compared with the lowest (median, 7.1 mg/d) quintiles for intake of flavonols and flavones after adjustment for age, obesity, smoking, intake of vitamin E, intake of alcohol, diabetes, hypertension, hypercholesterolemia, and family history of coronary heart disease. Among the 4814 men who reported that they had previously had coronary heart disease, we found a modest but nonsignificant inverse association between intake of flavonols and flavones and subsequent coronary mortality rates (relative risk, 0.63 [CI, 0.33 to 1.20] for the highest compared with the lowest quintile for intake of flavonoids).

Conclusion: The data do not support a strong inverse association between intake of flavonoids and total coronary heart disease, but they do not exclude the possibility that flavonoids have a protective effect in men with established coronary heart disease.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)