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Whither Recombinant Human Growth Hormone?

Christos S. Mantzoros, MD, DSc; and Alan C. Moses, MD
[+] Article, Author, and Disclosure Information

Beth Israel Deaconess Medical Center, Boston, MA 02215. Requests for Reprints: Alan C. Moses, MD, GZ 800, General Clinical Research Center, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215. Current Author Addresses: Drs. Mantzoros and Moses: GZ 800, General Clinical Research Center, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1996;125(11):932-934. doi:10.7326/0003-4819-125-11-199612010-00010
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Growth hormone and insulin-like growth factor 1 (IGF-1) are important anabolic hormones. They enhance intestinal absorption of calcium and phosphate and may play a direct role in DNA synthesis in bone, proliferation of osteoblasts, and accumulation of procollagen messenger RNA [12]. Although the actions of growth hormone were thought to be caused by circulating IGF-1 alone, recent evidence [12] suggests that growth hormone and other hormones stimulate local production of IGF-1, which acts in a paracrine-autocrine fashion in some tissues.

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