0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Results of Transplanting Bone Marrow from Genetically Identical Twins into Patients with Aplastic Anemia

Wolfgang Hinterberger, MD; Philip A. Rowlings, MD; Margareta Hinterberger-Fischer, MD; John Gibson, PhD, FRACP; Niels Jacobsen, MD; John P. Klein, PhD; Hans-Jochem Kolb, MD; Don A. Stevens, MD; Mary M. Horowitz, MD, MS; and Robert Peter Gale, MD, PhD
[+] Article and Author Information

For author affiliations and current author addresses, see end of text. Acknowledgments: The authors thank Melodee L. Nugent, MA, for data analysis and Dr. Mortimer M. Bortin, who provided guidance in design and initiation of this study before his death in July 1994. Grant Support: By Public Health Service grant PO1-CA-40053 from the National Cancer Institute, the National Institute of Allergy and Infectious Diseases, and the National Heart, Lung and Blood Institute; by contract CP-21161 from the National Cancer Institute of the U.S. Department of Health and Human Services; and by grants from Alpha Therapeutic Corp.; Amgen, Inc.; Applied Immune Sciences; Armour Pharmaceutical Co.; Astra Pharmaceutical; Baxter Healthcare Corp.; Bayer Corp.; Biogen; Blue Cross and Blue Shield Association; Lynde and Harry Bradley Foundation; Bristol-Myers Squibb Co.; Frank G. Brotz Family Foundation; the Cancer Center of the Medical College of Wisconsin; Center for Advanced Studies in Leukemia; Charles E. Culpeper Foundation; Eleanor Naylor Dana Charitable Trust; Eppley Foundation for Research; Genentech, Inc.; Glaxo Wellcome Co.; Hoechst Marion Roussel, Inc.; Immunex Corp.; Janssen Pharmaceutica; Kettering Family Foundation; Kirin Brewery Co.; Robert J. Kleberg Jr. and Helen C. Kleberg Foundation; Herbert H. Kohl Charities, Inc.; Eli Lilly Co. Foundation; Nada and Herbert P. Mahler Charities; Milstein Family Foundation; Milwaukee Foundation-Elsa Schoeneich Research Fund; Samuel Roberts Noble Foundation; Ortho Biotech Corp.; John Oster Family Foundation; Elsa U. Pardee Foundation; Jane and Lloyd Pettit Foundation; Alirio Pfiffer Bone Marrow Transplant Support Association; Pfizer, Inc.; Pharmacia Upjohn; RGK Foundation; Sandoz Pharmaceuticals; Schering-Plough International; Walter Schroeder Foundation; Stackner Family Foundation; Starr Foundation; Joan and Jack Stein Charities; and Wyeth-Ayerst Laboratories. Requests for Reprints: Mary M. Horowitz, MD, MS, International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226. Current Author Addresses: Drs. Hinterberger and Hinterberger-Fischer: Donauspital im Sozialmedizinischen, Zentrum Ost 2 Med. Abteilung, Langobardenstrasse 122, A-1220 Vienna, Austria. Drs. Rowlings and Horowitz: International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1997;126(2):116-122. doi:10.7326/0003-4819-126-2-199701150-00004
Text Size: A A A

Background: Aplastic anemia is caused by several diverse factors, including a lack of or defective hematopoietic stem cells, immune abnormalities, and disorders of the bone marrow microenvironment. The outcome of transplanting bone marrow from genetically identical twins into patients with aplastic anemia may help define how frequently these factors play a role in this condition.

Objective: To determine the outcome of transplanting bone marrow from genetically identical twins into patients with aplastic anemia.

Design: Observational study.

Setting: 31 centers participating in the International Bone Marrow Transplant Registry.

Patients: 40 patients with aplastic anemia who received bone marrow transplants from their genetically identical twins between 1964 and 1992.

Intervention: 23 patients received their first bone marrow transplant without pretransplantation conditioning; 17 received it after pretransplantation conditioning with cyclophosphamide alone or combined with other drugs or radiation. Six patients received post-transplantation immunosuppressive therapy with methotrexate, cyclosporine, and corticosteroids, alone or in combination.

Measurements: Outcomes of transplantation, including hematologic recovery and survival.

Results: Seven of 23 patients who received their first transplant without receiving conditioning had sustained complete hematologic recovery. One of 16 patients who did not have complete recovery after the first transplantation recovered after a second transplantation, which was not preceded by conditioning. The other 15 patients had two to five transplantations that were preceded by conditioning; in 13 patients, sustained bone marrow function was recovered. Twelve of 17 patients whose first transplantation was preceded by conditioning had sustained complete hematologic recovery. The likelihood of hematologic recovery was greater in patients who had conditioning before the first transplantation (P = 0.033). The actuarial 10-year survival rate for the 40 patients was 78% (95% CI, 59% to 92%). The survival rate was higher in patients who did not have conditioning before the first transplantation (patients without conditioning, 87% [range, 65% to 99%]; patients with conditioning, 70% [range, 47% to 89%]; P = 0.037).

Conclusions: Most patients with aplastic anemia recover bone marrow function after receiving a transplant from a genetically identical twin. Pretransplantation conditioning may increase the chance of bone marrow recovery but does not seem to improve survival.

Figures

Grahic Jump Location
Figure 1.
Outcome of transplanting bone marrow from genetically identical twins into 40 patients with aplastic anemia.

*Patient died of fungal pneumonia 3.5 months after first transplantation; † Patient died of septicemia 3.5 years after first transplantation; ‡ Patients died of fungal pneumonia (1 patient), the acute respiratory distress syndrome (1 patient), and diffuse alveolar hemorrhage (2 patients) 7, 12, 16, and 20 days after first transplantation, respectively. § Patient died of interstitial pneumonia, pneumothorax, and graft-versus-host disease 5 months after first transplantation. Values in parentheses are numbers of patients. BMT = bone marrow transplantation.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)