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Primary Biliary Cirrhosis: Questions and Promises

Keith D. Lindor, MD
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Mayo Clinic, Rochester, MN 55905 Requests for Reprints: Keith D. Lindor, MD, Division of Gastroenterology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1997;126(9):733-735. doi:10.7326/0003-4819-126-9-199705010-00010
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The article on biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment by Kaplan and colleagues [1] in this issue may be a landmark contribution. The authors force the reader to deal with a series of provocative issues, including redefinition of our understanding of the natural history of primary biliary cirrhosis and reevaluation of appropriate clinical end points for trials of treatment in this disease. They also raise the possibility that primary biliary cirrhosis is heterogeneous and should be further subtyped.

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