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Complete Sustained Response of a Refractory, Post-Transplantation, Large B-Cell Lymphoma to an Anti-CD22 Immunotoxin

Adrian M. Senderowicz, MD; Ellen Vitetta, PhD; Donna Headlee, RN; Victor Ghetie, PhD; Jonathan W. Uhr, MD; William D. Figg, PharmD; Richard M. Lush, PhD; Maryalice Stetler-Stevenson, MD, PhD; Glenn Kershaw, MD; Douglas W. Kingma, MD; Elaine S. Jaffe, MD; and Edward A. Sausville, MD, PhD
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From the National Cancer Institute, National Institutes of Health, Bethesda, Maryland; University of Massachusetts Medical Center, Worcester, Massachusetts; and University of Texas Southwestern Medical Center, Dallas, Texas. Grant Support: Extramural portions of the study were supported by National Institutes of Health grants CA28149 and CA41081. Requests for Reprints: Edward A. Sausville, MD, PhD, Developmental Therapeutics Program, National Cancer Institute, Executive Plaza North, Suite 843, 6130 Executive Boulevard, Rockville, MD 20852. Current Author Addresses: Dr. Senderowicz and Ms. Headlee: Medicine Branch, Division of Clinical Science, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1997;126(11):882-885. doi:10.7326/0003-4819-126-11-199706010-00005
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CD19, CD20, CD21, CD22: B-cell surface markers frequently expressed on the surface of B-cell tumors. The immunotoxin used in our patient is directed against CD22.

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Figure 1.
Findings in a patient with a refractory post-transplantation large B-cell lymphoma treated with an anti-CD22 immunotoxin.arrow

A. Biopsy specimen of the para-aortic lymphadenopathy shows large lymphoid cells with prominent central nucleoli (hematoxylin and eosin; original magnification, × 630). B. In situ hybridization of the percutaneous biopsy specimen with Epstein-Barr encoded RNA probe shows nuclear signal in all tumor cells (original magnification, × 630). C. Pretreatment computed tomographic scan at the level of the para-aortic adenopathy ( ). D. Computed tomographic scan at the level of the para-aortic adenopathy 9 months after the third course of immunotoxin therapy was completed.

Grahic Jump Location




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