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Putting Some Muscle into Osteoarthritis

Kenneth D. Brandt, MD
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Indiana University School of Medicine Indianapolis, IN 46202-5103 Acknowledgment: The author thanks Kathie Lane for expert secretarial assistance. Grant Support: In part by grants AR20582 and AR43348 from the National Institutes of Health. Requests for Reprints: Kenneth D. Brandt, MD, Rheumatology Division, 541 Clinical Drive, Room 492, Indianapolis, IN 46202.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1997;127(2):154-156. doi:10.7326/0003-4819-127-2-199707150-00011
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Osteoarthritis, the most common joint disease, results from the complex interplay of biochemical, metabolic, and biomechanical factors and is characterized, in part, by the progressive loss of articular cartilage. Aggrecan and collagen, the major molecular constituents of articular cartilage, confer stiffness on compression and tensile strength, respectively. Evidence that the metabolic turnover rates of these molecules are increased in osteoarthritic cartilage has led investigators to search for enzymes responsible for their degradation in the hope that pharmacologic inhibitors might be developed to prevent the development or slow the progression of osteoarthritis.

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