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Experimental Challenge of Volunteers with Malaria

Stephen L. Hoffman, MD, DTMH
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Naval Medical Research Institute; Bethesda, MD 20889-5607 Grant Support: By Naval Medical Research and Development Command Work Units Nos. 61102A00101.BFX-1431 and 62787A00101.EFX-1432. Requests for Reprints: Stephen L. Hoffman, MD, DTMH, Malaria Program, Naval Medical Research Institute, Bethesda, MD 20889-5607.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1997;127(3):233-235. doi:10.7326/0003-4819-127-3-199708010-00010
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As physicians sworn to “do no harm” and clinical investigators working to develop malaria vaccines and drugs, my colleagues and I have had to repeatedly ask ourselves whether it is ethical to conduct experimental studies of malaria challenge in volunteers. We have discussed that question with members of human trial committees, volunteers, colleagues, and friends and family, many of whom have initially been incredulous to hear that persons volunteer to be infected with the parasites that cause malaria.



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