The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Reduced Plasma Concentrations of Antituberculosis Drugs in Patients with HIV Infection

Jan Sahai, PharmD; Keith Gallicano, PhD; Lori Swick, BSc; Sandra Tailor, PharmD; Gary Garber, MD; Isabelle Seguin, RN; Linda Oliveras, MLT; Scott Walker, MSc; Anita Rachlis, MD; and D. William Cameron, MD
[+] Article, Author, and Disclosure Information

From the University of Ottawa at the Ottawa General Hospital and Health Canada, Ottawa, Ontario, Canada; and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Acknowledgments: The authors thank Attila Pakuts (Health Canada) and Nicole Lee (Ottawa General Hospital) for technical assistance and Eric Ormsby and Bob Li (Health Canada) for statistical advice. Grant Support: In part by the Burroughs Wellcome Positive Action Program, administered by the Ontario Ministry of Health, Ontario, Canada. Dr. Cameron is a Career Scientist of the Ontario Ministry of Health (award #02984). Requests for Reprints: Keith Gallicano, PhD, Clinical Investigation Unit, Ottawa General Hospital, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada. Current Author Addresses: Dr. Sahai: Hoffmann-La Roche, Pharmaceutical Division, BioMed Business Unit, 2455 Medowpine Boulevard, Mississauga, Ontario L5N 6L7, Canada.

Copyright ©2004 by the American College of Physicians

Ann Intern Med. 1997;127(4):289-293. doi:10.7326/0003-4819-127-4-199708150-00006
Text Size: A A A

Background: Reports suggest that antituberculosis drugs are malabsorbed in patients with advanced HIV disease.

Objective: To evaluate the pharmacokinetics of antituberculosis agents in HIV-seropositive patients at different stages of disease.

Design: Parallel study.

Setting: Two hospital outpatient clinics.

Participants: 12 healthy volunteers, 12 patients with asymptomatic HIV disease, 12 patients with symptomatic HIV disease, and 12 patients with symptomatic HIV disease and diarrhea.

Measurements: Drug plasma concentrations were measured over 24 hours on day 4 of concurrent therapy.

Intervention: Oral isoniazid (300 mg/d), rifampin (600 mg/d), pyrazinamide (1000 mg/d), and ethambutol (1000 mg/d).

Results: Reduced total drug exposure to rifampin and pyrazinamide was associated with D-xylose malabsorption in persons with HIV infection or AIDS. Peak drug exposure to isoniazid was lower in patients with diarrhea.

Conclusions: Reduced total drug exposure may be related to malabsorption in persons with HIV infection or AIDS.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $32.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.