0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

ACE Gene Polymorphism as a Risk Factor for Ischemic Cerebrovascular Disease

Birgit Agerholm-Larsen, MS; Anne Tybjaerg-Hansen, MD, DMSc; Ruth Frikke-Schmidt, MD; Marie-Louise M. Gronholdt, MD; Gorm Jensen, MD, DMSc; and Borge G. Nordestgaard, MD, DMSc
[+] Article and Author Information

From the Herlev University Hospital, Herlev, Denmark; and National University Hospital and University of Copenhagen, Copenhagen, Denmark. Acknowledgments: The authors thank Poul Westermann and Mette Refstrup for technical assistance and Merete Appleyard for advice on the Copenhagen City Heart Study database. Grant Support: By the Danish Heart Foundation, the Danish Research Academy, Copenhagen County, and Chief Physician Johan Boserup's and Lise Boserup's Fund. Requests for Reprints: Borge G. Nordestgaard, MD, DMSc, Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark. Current Author Addresses: Ms. Agerholm-Larsen and Drs. Tybjaerg-Hansen Frikke-Schmidt, and Nordestgaard: Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1997;127(5):346-355. doi:10.7326/0003-4819-127-5-199709010-00002
Text Size: A A A

Background: Researchers have suggested that the deletional allele of the ACE (angiotensin-converting enzyme) gene insertion-deletion polymorphism is a potent risk factor for myocardial infarction. This association could not be confirmed in the Copenhagen City Heart Study, in which 10 150 persons were studied. The ACE gene polymorphism has also recently been suggested as a potent risk factor for ischemic cerebrovascular disease.

Objective: To investigate the association between ACE gene polymorphism and ischemic cerebrovascular disease.

Design: Two case-referent studies and a cross-sectional study.

Setting: University hospital in Copenhagen, Denmark.

Participants: Case-referent study 1: 35 women and 38 men who developed ischemic cerebrovascular disease before 50 years of age compared with 1454 women and 1737 men from a general population sample. Case-referent study 2: 82 women and 137 men with ischemic cerebrovascular disease and carotid stenosis greater than 40% compared with 4273 women and 3091 men from the general population sample. Cross-sectional study of the general population sample: 67 women and 93 men with ischemic cerebrovascular disease compared with 4077 women and 3156 men without such disease.

Measurements: Genotype; age; body mass index; smoking habits; levels of lipids, lipoproteins, apolipoproteins, and fibrinogen; and diagnosis of hypertension, diabetes mellitus, and ischemic cerebrovascular disease.

Results: Odds ratios for ischemic cerebrovascular disease by ACE genotype classes were not significantly different from 1.0 in women or men in any of the three studies, separately or combined. In a logistic regression analysis that controlled for age and conventional cardiovascular risk factors, odds ratios in either sex still did not significantly differ from 1.0 in any study, separately or combined.

Conclusion: In two case-referent studies, a cross-sectional study, and the three studies combined, no statistically significant difference was found in the development of ischemic cerebrovascular disease between genotype classes of the ACE gene polymorphism in women or men.

Figures

Grahic Jump Location
Figure 1.
Study designs.

Arrows indicate groups compared in the three studies.

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)