0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Simplified Screening for Microalbuminuria

Alfredo Pegoraro, MD; Ashok Singh, PhD; Asad A. Bakir, MD; Jose A.L. Arruda, MD; and George Dunea, MD
[+] Article and Author Information

From Cook County Hospital, University of Illinois at Chicago, West Side Veterans Administration Hospital, and the Hektoen Institute for Medical Research, Chicago, Illinois. Acknowledgments: We thank Nijole Stankeviciute, MD, Sharlyn Miranda, MD, and Jyoti Sharma, MD, for assistance in performing radioimmunoassay and other laboratory activities and Jewel Wallace for typing the manuscript. Requests for Reprints: Alfredo Pegoraro, MD, Section of Nephrology, Cook County Hospital, 637 South Wood Street, Chicago, IL 60612. Current Author Addresses: Drs. Pegoraro, Singh, Bakir, and Dunea: Section of Nephrology, Cook County Hospital, 637 South Wood Street, Chicago, IL 60612.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1997;127(9):817-819. doi:10.7326/0003-4819-127-9-199711010-00007
Text Size: A A A

Background: Screening for microalbuminuria is increasingly advocated as a way to diagnose early renal involvement in diabetes and other diseases. It usually entails the use of a radioimmunoassay that is expensive and not always readily available.

Objective: To assess the efficacy of three simple and inexpensive tests for ruling out microalbuminuria.

Design: Cross-sectional study.

Setting: Outpatient clinics.

Patients: 221 patients from primary care clinics and a diabetes clinic.

Measurements: Random urine specimens were tested for albumin by using Micral-Test immunoassay strips (Boehringer Mannheim, Mannheim, Germany) and for protein by using sulfosalicylic acid testing and impregnated dipsticks (Chemstrips, Boehringer Mannheim). Radioimmunoassay for albumin was used for all specimens as standard for comparison.

Results: When less than 20 mg/L was considered the upper limit of normal for albumin concentration, Micral-Test, sulfosalicylic acid testing, and Chemstrips had negative predictive values of 99%, 95%, and 96%, respectively. Seventy-four specimens tested negative on both sulfosalicylic acid and Chemstrips; the negative predictive value of these two tests combined was 99%.

Conclusions: The combination of sulfosalicylic acid testing and Chemstrips was as good as and less expensive than Micral-Test in ruling out microalbuminuria.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)