0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Hydroxyurea-Induced Leg Ulceration in 14 Patients

Patricia J. Best, MD; Mazen S. Daoud, MD; Mark R. Pittelkow, MD; and Robert M. Petitt, MD
[+] Article and Author Information

From Mayo Clinic and Mayo Foundation, Rochester, Minnesota. Requests for Reprints: Mark R. Pittelkow, MD, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Current Author Addresses: Dr. Best: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;128(1):29-32. doi:10.7326/0003-4819-128-1-199801010-00005
Text Size: A A A

Background: Hydroxyurea is an antineoplastic agent commonly used to treat myeloproliferative disorders and other nonneoplastic conditions.

Objective: To further define the typical features of hydroxyurea-related cutaneous ulcers of the leg.

Design: Retrospective, descriptive study of the medical records of patients who developed leg ulcers while receiving hydroxyurea therapy.

Setting: A tertiary care medical center.

Patients: Patients with myeloproliferative disorders who were treated with hydroxyurea.

Results: 14 patients with extremely painful leg ulcers were identified. The most common ulcer site was the malleoli. Multiple ulcers were seen in 64% of patients. Patients had received hydroxyurea for an average of 6 years before ulcers developed. All ulcers healed after discontinuation of hydroxyurea treatment, and 2 patients developed ulcers after treatment was restarted.

Conclusion: Hydroxyurea induces painful leg ulcers that are usually difficult to treat and require cessation of hydroxyurea therapy.

Topics

ulcer ; hydroxyurea ; leg

Figures

Grahic Jump Location
Figure 1.
Hydroxyurea-induced ulcer. Top.Bottom.

Shallow, polyangular, punchedout ulceration on the left lateral malleolus of a patient receiving hydroxyurea treatment. Note the porcelain-colored scar from a healed ulcer. Photomicrograph of a skin biopsy specimen from the border of a typical hydroxyurea-induced ulcer. Note the papillary dermal edema, vessel hyalinization, and perivascular lymphocytic inflammation. (Hematoxylin and eosin; original magnification, x40.).

Grahic Jump Location

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)