0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Radiation Therapy for Breast Cancer and Increased Risk for Esophageal Carcinoma

Habibul Ahsan, MD, MMedSc; and Alfred I. Neugut, MD, PhD
[+] Article and Author Information

Requests for Reprints: Habibul Ahsan, MD, MMedSc, Division of Epidemiology, Columbia School of Public Health, 600 West 168th Street, New York, NY 10032. Current Author Addresses: Dr. Ahsan: Division of Epidemiology, Columbia School of Public Health, 600 West 168th Street, New York, NY 10032.


Copyright ©2004 by the American College of Physicians


Ann Intern Med. 1998;128(2):114-117. doi:10.7326/0003-4819-128-2-199801150-00007
Text Size: A A A

Background: Several case reports have suggested an association between radiation therapy for breast cancer and the subsequent occurrence of esophageal carcinomas.

Objective: To examine the association between radiation therapy for breast cancer and subsequent esophageal squamous-cell carcinomas and adenocarcinomas.

Design: Population-based retrospective cohort study.

Setting: Population-based U.S. cancer registries.

Patients: 220 806 women in whom breast cancer was diagnosed between 1 January 1973 and 31 December 1993; 1 216 853 person-years of follow-up.

Measurements: Age- and period-adjusted standardized incidence ratio as a measure of relative risk for the second primary cancer.

Results: In women who had received radiation therapy for breast cancer, the relative risk for esophageal squamous-cell carcinoma increased to 5.42 (95% CI, 2.33 to 10.68) and the relative risk for esophageal adenocarcinoma increased to 4.22 (CI, 0.47 to 15.25) 10 or more years after radiation therapy. No increased risk was seen for either type of carcinoma among patients with breast cancer who did not receive radiation therapy.

Conclusion: The risk for esophageal carcinoma is increased in women who receive radiation therapy for breast cancer.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)